Biochem/physiol Actions
Reversible: no
Primary TargetDNA topoisomerase I
Product does not compete with ATP.
Cell permeable: yes
General description
A cell-permeable, powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Inhibits the proliferation of hepatoma HepG2, Bcl-7402 and Bcl-7404 cells in a dose-dependent manner. Has selective inhibitory effect on the phosphorylation of histones H1 and H3, but is less effective on other histones.
A cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Zhang, X.W., et al. 1999. Anticancer Drugs.10, 569.Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.Wani, M.C., and Wall, M.E. 1969. J. Org.Chem.34, 1364.
Packaging
25 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Irritant (B)
This product has met the following criteria to qualify for the following awards: